Harvard Team Zeroing in on How Life Arose from Nonliving Molecules
August 29, 2009
I found the following article, which was posted two days ago by Casey Kazan, on “The Daily Galaxy” website… As it is a subject of great importance, one who’s results might have great implications about the way We perceive ourselves here on Earth, I follow it adamantly.

How did life on Earth begin? An giant step toward solving this puzzle was taken in the 1980′s with the Nobel Prize–winning discovery by Tom Cech and Sidney Altman that RNA, the sister molecule of DNA, can catalyze certain chemical reactions inside cells, a job previously thought to be the exclusive domain of proteins. Until their discovery, RNA was thought to have just one function: storing the genetic information cells need to build proteins.
This new revelation about RNA’s dual role suggested to some scientists, including Harvard’s Jack Szostak, that RNA likely existed long before DNA or proteins because it might be able to catalyze its own reproduction. Their discovery made it easier to think about how life began, Szostak says. “They inspired me to try to think of ways to make RNAs in the lab that could catalyze their own replication.”
Szostak and his team is working to recreate a hypothetical model of this process in the laboratory. By building simple cell-like structures in a test tube, they are attempting to establish a plausible path that led primitive cells to emerge from simple chemicals. Ultimately, Szostak hopes to answer fundamental questions about evolution’s earliest steps.
Building on earlier work by other scientists, Szostak and colleagues began experimenting with a clay mixture common on early Earth called montmorillonite, which was found to catalyze the chemical reactions needed to make RNA.
Montmorillonite is a very soft phyllosilicate group of minerals that typically form in microscopic crystals, forming a clay. It is named after Montmorillon in France. Montmorillonite, a member of the smectite family, is a 2:1 clay, meaning that it has 2 tetrahedral sheets sandwiching a central octahedral sheet. The particles are plate-shaped with an average diameter of approximately one micrometre. Members of this group include saponite. It is the main constituent of the volcanic ash weathering product, bentonite. The water content of montmorillonite is variable and it increases greatly in volume when it absorbs water. Chemically it is hydrated sodium calcium aluminium magnesium silicate hydroxide (Na,Ca)0.33(Al,Mg)2(Si4O10)(OH)2·nH2O. Potassium, iron, and other cations are common substitutes, the exact ratio of cations varies with source. It often occurs intermixed with chlorite, muscovite, illite, cookeite and kaolinite.
So, did life originally spring from clay as some creation myths assert? Not necessarily, but it does provide a possible mechanism for explaining how life initially arose from nonliving molecules. Szostak’s team at the Howard Hughes Medical Institute and Massachusetts General Hospital showed that the presence of clay aids naturally occurring reactions that result in the formation of fatty sacks called vesicles, similar to what scientists expect the first living cells to have looked like. Further, the clay helps RNA form. The RNA can stick to the clay and move with it into the vesicles. This provides a method for RNA’s critical genetic information to move inside a primitive cell.
“It’s exciting because we know that a particular clay mineral helps with the assembly of RNA,” Szostak said. “There certainly would have been lots of environments on early Earth with clay minerals. It’s something that forms relatively easily as rocks weather.”
The researchers also found that the clay expedited the process by which fatty acids form vesicles that could serve as cell membranes. When RNA and fatty acids were mixed with the montmorillonite, the clay seemed to help transport the RNA inside the vesicles, forming a cell-like structure. Szostak and his team surmised that a similar process could possibly have led to the creation of the first cell.

At 3:00 p.m. Alaska Daylight Time on May 23, 2006, Flight Engineer Jeff Williams from International Space Station (ISS) Expedition 13 contacted the Alaska Volcano Observatory (AVO) to report that the Cleveland Volcano had produced a plume of ash. Shortly after the activity began, he took this photograph. This picture shows the ash plume moving west-southwest from the volcano’s summit. A bank of fog (upper right) is a common feature around the Aleutian Islands. The event proved to be short-lived; two hours later, the plume had completely detached from the volcano (see image from May 24). The AVO reported that the ash cloud height could have been as high as 6,000 meters (20,000 feet) above sea level.
When the Earth and Moon were cooling from the forces of accretion, no doubt there would have been thousands of volcanic ash plumes blooming in the proto-atmosphere, as the brittle mantle overflowed with hot magma and molten rock… And as the Earth’s surface cooled, water would have condensed out from the atmosphere and dissolved some of the ash. This would have begun the cycle of accumulation of this clay, as it deposited in ever increasing amounts over the surface of the Earth.
If you are curious about the source of this article, please click here.

[...] mechanisms of biological atomic machinery and their resulting cyclic reactions. No doubt, when life got out of this cyclic molecular rut, and the first highly successful single celled organisms began to colonize the Earth nearly four [...]
[...] Life. This is how chaos’ beautiful flow caused a wondrous event which give rise to all of the Life here on planet Earth. Here lies the key to seeing how we came into being. This is the same powerful [...]
[...] I hear you say. And all I’m gonna say is that… A recent mathematical analysis says that Life, as we know it, is written into the laws of [...]
[...] way through to “Just How Did Life Seed Here On Earth?” Along with clangers like “Might We Be Able To Create Life In The Laboratory To Recreate Those Initial Conditions That Gave Ris…?” And, would you believe, I even thought I could attempt to discuss “What This [...]
You obviously didn’t read the blog then.
[...] as human beings, are beginning to figure out how life, as we know it, arose from a sea of seemingly non-living molecules… And we’ve even seen how the fine line between everyday non-living bio-chemistry mimics [...]